In a June 22, 2020, Orthomolecular Medicine News Service press release, 1 Damien Downing, president of the British Society for Ecological Medicine, outlines how we could resolve the COVID-1 9 pandemic in 30 days for about$ 2 per person, simply by taking affirmative action to raise vitamin D tiers. The downside or gamble of doing this is basically nil, while the potential gain could be avoiding another COVID-1 9 spike altogether.
“If we could arrange to give everyone vitamin D, and it failed to protect them, so what? The probability from not behaving is much larger than the risk from playing, ” Downing says, contributing: “If you caught the COVID1 9 virus right now, having a good vitamin D status( from previously having taken a supplement) would
Reduce your risk of the disease becoming severe by 90%
Reduce your risk of dying by 96%
This is not ‘proven’ or ‘evidence-based’ until we have done controlled visitations likening it to placebo … But the data, already strong, has been pouring in since the start of the pandemic.”
Although the required prospective randomized restrained inquiries employing vitamin D have not yet been ended, they are indeed underway and arising as a result of many will be in before year’s end. You can tour the clinical inquiries registry to review the current state of these contests. 2,3 As of June 2020, there is indeed over 20 studies in progress on the use of vitamin D in COVID-1 9.
Vitamin D and COVID-1 9
Downing goes on to quote the studies and supporting data. Among them is a study4 from the Philippines, which found that for each standard irregularity increase in serum vitamin D, the quirkies of experiencing exclusively mild canker rather than severe illness was 7.94 times larger, and the curious of having a slight clinical aftermath rather than a critical outcome was 19.61 times greater. Harmonizing to the author 😛 TAGEND
“The ensues suggest that an increase in serum 25( OH) D position in the body could either improve clinical aftermaths or mitigate worst( severe to critical) outcomes, while a decrease in serum 25( OH) D level in the body could worsen clinical outcomes of COVID-2 019 patients.”
Another study5 from Indonesia, which looked at data from 780 COVID-1 9 cases, perceived those with a vitamin D stage between 20 ng/ mL( 50 nmol/ L) and 30 ng/ mL( 75 nmol/ L) had a sevenfold higher risk of extinction than those with a degree above 30 ng/ mL. Having a rank below 20 ng/ mL was associated with a 12 times higher risk of demise. As noted by Downing: 6
“With a impaired vitamin D status (< 50 nmol/ L) the mortality from COVID-1 9 was 98.8% against 4.1% with adequate vitamin D (> 75 nmol/ L ). The Hazard Ratio is 24.1 … A Hazard Ratio of 4 means that in one condition, for instance vitamin D shortage, “youre gonna” 4 times more likely to suffer the ‘hazard’ than in another condition, say vitamin D adequacy.”
A third paper, 7 which provides data from 20 European countries, likewise found that “the probability of developing COVID-1 9, and of dying from it, is negatively related with convey population vitamin D status, with both likelihoods reaching zero above about 75 nmol/ L, “( 30 ng/ mL) Downing documents. 8P TAGEND
A vitamin D3 blood level of at least 75 nmol/ L( 30 ng/ ml) is needed for protection against COVID-1 9.
In their preprint submission of this paper, 9 the scribes concluded, “We believe that we can advise vitamin D supplementation to protect against SARS-CoV2 infection.” Downing made the following graph1 0 to illustrate the data in that paper.
Vitamin D Level Above 30 ng/ mL Protects You Against COVID-1 9
Downing too addresses the issue of dosage and safety, highlighting how urges about “excessive vitamin D intakes” being risky are very misleading and unwarranted, as toxicity has not been demonstrated until you punched blood elevations above 200 ng/ mL( 500 nmol/ L ).
The recommended blood statu for optimal health is currently between 60 ng/ mL( 150 nmol/ L) and 80 ng/ mL( 200 nmol/ L ). In other oaths, there’s a significant margin of safety, even though they are you manage to transcended the optimal range.
“The three papers1 1,12, 13 mentioned above show that a vitamin D3 blood level of at least 75 nmol/ L( 30 ng/ ml) is needed for protection against COVID-1 9, ” Downing writes. 14
“Government recommendations for vitamin D uptake — 400 IU/ day for the UK and 600 IU/ daytime for the USA ( 800 IU for> 70 years) and the EU — are based primarily on bone health. This is woefully inadequate in the pandemic context.
An adult will need to take 4,000 IU/ era of vitamin D3 for three months to reliably reach a 75 nmol/ L position. 15 Beings of colouring may need twice as much. 16 These quantities can reduce the risk of infection, but are not for treatment of an acute viral infection.
And since vitamin D is fat-soluble and its level in their own bodies rises slowly, for those working with a paucity, taking an initial quantity of 5-fold the normal dose( 20,000 IU/ epoch) for two weeks can help to raise the level up to an adequate level to lower infection risk.”
Become Metabolically Flexible and Insulin Sensitive
As discussed in my interview with Dave Asprey, featured in “How Ketones May Be Useful Against COVID-1 9, ” being metabolically flexible is another important lifestyle component. The reason for this is because insulin resistance attains you more prone to cytokine cyclone, a primary cause of death among COVID-1 9 patients.
The single most important step you can take to reach metabolic opennes is to cut down the hours during which you feed. More than 90% of beings eat for more than 12 hours a day, and more than half devour for more than 16 hours a day. The key reduction of your eating opening to six to eight hours, doing sure the last food you gobbled is at least three hours before you go to bed.
When you inhibit your eating window you are able to decrease insulin resistance, are becoming ever more metabolically resilient and able to seamlessly switch back and forth between burning solid or carbs as your primary ga. I wrote an entire volume on how to become metabolically adaptable, “Fat for Fuel, ” but a simple summary is as follows 😛 TAGEND
Time-restrict your eating opening to six to eight hours
Eliminate all industrially managed vegetable oils
Limit carbs to 50 grams per day until metabolically flexible and then increase to 150 grams of healthy carbs twice a few weeks
This strategy is absolutely vital in light of the prevalence of insulin opposition. Over 90% of the U.S. is vitamin D insufficient; 90% of the person is also insulin resistant. Research1 7 published in Metabolic Syndrome and Related Disorders in February 2019 concluded that 87.8% of the U.S. adults sampled were metabolically rigid, which means they cannot efficiently burn overweight for fuel.
Ketones May Also Be Useful Against COVID-1 9
When “youre gonna” insulin feelings, metabolically adaptable and eating a cyclical low-carb diet, you will be able to generate healthy ketone status. Remember that constant ketosis and low-carb is an unhealthy strategy. It is fine to go low-carb for a few months, but for optimal health you need to cycle health carbs back in once or twice a few weeks, ideally when you are doing your hardest exercise or resist training of the week.
When you burn sugar for fuel, there is a requirement to break glucose down to two molecules of 3 carbon pyruvate. Pyruvate is then used by your mitochondria after it is converted to acetyl CoA. Insulin resistance, in turn, can impair the enzyme that proselytizes a disturbance make of glucose into pyruvate so it can be shuttled and burned as power in your mitochondria.
The problem with COVID-19 is that the cytokine storm inhibits the enzyme converting pyruvate to acetyl CoA
NADPH is the battery of your cell
NADPH also turns off NLRP3 inflammasome that produces cytokines like TNF alpha
All of that said
To address insulin resistance and metabolic inflexibility in the long termMolecular Hydrogen
Molecular hydrogen( H2 gas) has potent antioxidant and anti-inflammatory impressions, 18 constructing it is helpful for COVID-1 9 by reducing inflammatory cytokines, as explained in this video by Tyler W. LeBaron, founder of the science-based nonprofit Molecular Hydrogen Institute.
In his video, LeBaron examines the pathophysiology of COVID-1 9 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen might ameliorate this particular disease.
Molecular hydrogen or H2 has the ability to activate the Nrf2/ keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 improves govern and maintain homeostasis in the whole system, foreclosing the illnes from coming out of limitation and generating cadre demise.
Hydrogen can also downregulate NOX and NOS enzymes, thus lowering superoxide and nitric oxide make respectively. This is good, as when these two molecules are increased too much they instantly compound to create the detrimental peroxynitrite molecule. H2 likewise supports your mitochondrial capacity. Importantly, H2 selectively increases peroxynitrites and hydroxyl radicals.
H2 likewise steps in to prevent a cytokine gust from following. For a written epitome of LeBaron’s video chide, look “How Molecular Hydrogen Can Help Against COVID-1 9.” H2 will also help improve NADPH, and parts synergistically with time-restricted dining and cyclical ketosis.
Quercetin Plus Zinc May Lower COVID-1 9 Risk Further
In addition to vitamin D optimization, quercetin — which acts similarly to the pharmaceutical hydroxychloroquine — and zinc1 9 may further lower the health risks of COVID-1 9. Compelling testify proposes the reason hydroxychloroquine materializes so useful in the management of COVID-1 9 is a zinc ionophore, implying it improves zinc uptake into the cadre.
Quercetin has the same effects. In actuality, one study2 0 has suggested the biological actions — which include antiviral effects — of quercetin may in fact relevant to its ability to increase cellular zinc uptake.
Zinc is vital for health immune function2 1 and a combination of zinc with a zinc ionophore( zinc delivery molecule) was in 2010 indicate to hinder SARS coronavirus in vitro. In cell culture, the committee is also blocked viral replication within hours. 22 Conversely, zinc flaw has been shown to impair immune function. 23 As was contained in a 2013 paper on zinc flaw: 24
“Zinc is a second messenger of immune cells, and intracellular free zinc in these cadres participate in signaling happens. Zinc … is very effective in lessen the incidence of infection in the elderly. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent.”
The problem is that zinc is predominantly insoluble and cannot easily enter through the fatty wall of your cadres. Coming all the way into the cell is crucial, as this is where the viral replication pass. This is where zinc ionophores such as quercetin come in.
Quercetin is also a potent antiviral in its own right, and has the added advantage of restraint the 3CL protease2 5 — an enzyme used by SARS coronaviruses to infect health cadres. 26 According to one 2020 study, 27 the ability of quercetin to restraint SARS coronaviruses “is presumed to be directly linked to suppress the pleasure of SARS-CoV 3CLpro in some cases.”
To this you could also add niacin( vitamin B6) and selenium, as both toy important roles in the absorption and bioavailability of zinc in their own bodies. For example, a study2 8 be made available in 1991 proving that when young women were on a vitamin B6-deficient diet, their serum zinc declined, suggesting B6 deficiency changed zinc metabolism such that “absorbed zinc was not available for utilization.”
A more in-depth journey and explanation of both niacin and selenium’s relationship to zinc is laid down in the 2008 article, “Zinc, Metallothioneins and Longevity: Interrelationships With Niacin and Selenium.”2 9
The MATH Protocol
If you are hospitalized with COVID-1 9, early management becomes prime. While there’s a great deal of controversy over which treatment is best, clinical ground clearly advocates mechanical ventilation should be avoided at all costs. I discussed the reasons for this in “Ventilators May Increase Risk of Death From COVID-1 9.”
Furthermore, while hydroxychloroquine combined with zinc looms effective, I trust one of the most wonderful treatments recommended so far is the MATH+ Protocol. The protocol was developed by the Front Line COVID-1 9 Critical Care Working Group, 30 which includes Dr. Paul Marik, chief of the Division of Pulmonary& Critical Care Medicine at Eastern Virginia Medical School Norfolk, and boasts a near-1 00% effectiveness rate.
The MATH+ Protocol is designed to treat the second phase of COVID-1 9 infection — the stage when the hyperinflammatory immune response specifies in. For best makes, it is imperative to dispensed early enough, though. The MATH+ protocol3 1 calls for the use of the following three medicines, all of which need to be started within six hours of hospital admittance:
Intravenous methylprednisolone, to suppress the immune system and prevent organ damage from cytokine gales — For slight hypoxia, 40 milligrams( mg) daily until off oxygen; moderate to severe illness, 80 mg bolus been accompanied by 20 mg per day for seven days. On Day 8, switch to oral prednisone and diminish down over the next six eras.
Intravenous ascorbic acid( vitamin C ), to dominate irritation and prevent the development of leaky blood vessels in the lungs — 3 grams/ 100 ml every six hours for up to seven days.
Subcutaneous heparin( enoxaparin ), to thin the blood and avoid blood clots — For slight to moderate illness, 40 mg to 60 mg daily until discharged.
Optional additives include thiamine, zinc and vitamin D. In addition to these prescriptions, the protocol calls for high-flow nasal oxygen to avoid mechanical ventilation that can damage the lungs.
Together, this approach homes the three core pathological processes seen in COVID-1 9, namely hyperinflammation, hypercoagulability of the blood, and hypoxia( shortness of breath due to low-pitched oxygenation ).
COVID-19 Doesn’t Have to Remain a Crisis
Health experts are informing we’re likely to see a second brandish of COVID-1 9 this come. I repute the strategies reviewed in this article can go now a long way toward minimise fatalities.
The first thing I recommend everyone do is to optimize your vitamin D the summer months. Again, the optimal blood stage for health and disease prevention is between 60 ng/ mL and 80 ng/ mL.( In Europe, the measurements you’re looking for are 150 to 200 nmol/ L and 100 nmol/ L respectively .)
However, simply coming above 30 ng/ mL( 75 nmol/ L) may dramatically reduce your risk of serious infection and death, and doing so is both easy and inexpensive. As stated by Downing, we could fix the COVID-1 9 pandemic in as little as 30 epoches simply by making use of sure everyone is taking vitamin D in sufficiently large dosages.
More detailed information about how vitamin D directs and why it’s so important against COVID-1 9 was located in my Vitamin D Report. Download and share! You can also find a summary of the key steps it is required to to be undertaken to optimize your tier in this previous vitamin D article. Here is the link to my extensive science report.
I want to thank those of you who read the above report and required productive feedback. I miss you to know that I did speak those suggestions. I had already projected on writing a short summary, but the responses were nearly universal in support of that.
So, when you sounds the button below, you are able to get the compressed report that you can send to your friends and family and get them on board with the Vitamin D Campaign, which not only can save numerous lives, but can help prevent the country from been closed down again and aggravate our already impaired economy.
Taking quercetin and zinc is another preventive approach worth noting, as is the advice to implement cyclical nutritional ketosis to make sure you’re metabolically resilient and not insulin resistant. Again, you can do this by following three strong approaches 😛 TAGEND
Time-restricted eating window of six to eight hours
Eliminating all industrially managed vegetable oils
Limiting carbs to 50 grams a day until metabolically flexible and then increasing to 150 grams of healthy carbs twice a few weeks
More acutely, ketone esters may offer rapid aid of COVID-1 9-related evidences such as shortness of breath, and the MATH+ Protocol, administered within six hours of hospitalization, could be a life saver.
While the Front Line COVID-1 9 Critical Care Working Group has been struggling to get the word out to doctors and hospitals, you have been able( at naked minimum) request your doctor contact them and urge them to implement the etiquette should you or someone you adore get ill and need hospitalization.
Read more: articles.mercola.com
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